Adrucil and Mitomycin Intravenous

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

The use of mitoMYcin has been associated with a condition known as hemolytic uremic syndrome (HUS), and using it with fluorouracil may increase that risk. HUS is a disorder where red blood cells are destroyed by toxic substances produced by an infection. The damaged red blood cells can clog the filtering system in the kidneys and cause kidney failure. Fatality may occur in up to 50% of cases. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Consult with your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR CLOSELY: Fluorouracil may increase the risk of hemolytic uremic syndrome (HUS) associated with mitomycin C. HUS can be fatal in up to 50% of affected patients. The mechanism of this interaction and incidence are unknown. It has been suggested that the symptoms may be exacerbated by blood transfusions.

MANAGEMENT: Patients should be carefully monitored with frequent and regular CBCs as well as serum BUN and creatinine measurements. The authors of a case report suggest that treatment should be interrupted at the first signs of intravascular hemolysis, proteinuria, and rising urea.

Adrucil

Generic Name: fluorouracil

Brand name: Adrucil

Synonyms: Adrucil (injection)

What is Adrucil?

Mitomycin Intravenous

Generic Name: mitomycin

Brand name: Mutamycin

Synonyms: Mitomycin, MitoMYcin (Systemic)

What is Mitomycin Intravenous?