Adrucil injection and Flagyl

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Ask your doctor before using fluorouracil together with metroNIDAZOLE. Using fluorouracil together with metroNIDAZOLE can increase the blood levels or add to the side effects of fluorouracil. This can cause extreme fatigue, easy bruising or bleeding, black, bloody or tarry stools, fever, sores in the mouth or throat, vomiting, and diarrhea. You may need a dose adjustment or special tests to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Coadministration with a nitroimidazole may increase the toxicity of 5-fluorouracil (5-FU). The interaction has been observed with both metronidazole and misonidazole. The proposed mechanism involves reduced clearance of 5-FU in the presence of nitroimidazoles. In a study of 27 patients with metastatic colorectal cancer who received metronidazole (750 mg/m2 IV) an hour before 5-FU (600 mg/m2 IV) on five consecutive days per week every 4 weeks, an unusually high incidence of fluorouracil toxicity was observed, including granulocytopenia (74%), anemia (41%), stomatitis and oral ulceration (34%), nausea and vomiting (48%), and thrombocytopenia (19%). In another study, 15 patients receiving 5-FU (1 gm/m2) with misonidazole 2 gm/m2 or 3 gm/m2 for advanced colorectal cancer had an increased incidence (44% and 56%, respectively) and severity of nausea and vomiting compared to administration of 5-fluorouracil alone (27%) in a prior course. The incidence of leukopenia was also higher with the combination than 5-FU alone (18% versus 13%), although the difference was not statistically significant. Despite an increase in toxicity, in vitro studies performed by the first group of investigators failed to detect any additive or synergistic antineoplastic effect secondary to the interaction.

MANAGEMENT: Given the potential for increased toxicity, 5-fluorouracil and its prodrugs, capecitabine and tegafur, should probably not be used with nitroimidazoles unless benefits are anticipated to outweigh the risks.

Adrucil injection

Generic Name: fluorouracil

Brand name: Adrucil

Synonyms: Adrucil (injection), Adrucil

What is Adrucil injection?

Flagyl

Generic Name: metronidazole

Brand name: Flagyl, FIRST Metronidazole, Flagyl 375, MetroGel

Synonyms: n.a.

What is Flagyl?