Adrucil injection and Vincristine
Determining the interaction of Adrucil injection and Vincristine and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration of fluorouracil and vincristine may lead to an earlier onset and/or increased severity of side effects. The mechanism is inhibition of the metabolism of both drugs by a hepatic cytochrome P-450 isoenzyme in the CYP 3A subfamily. The clinical significance of this interaction has not been established. If fluorouracil and vincristine are used concomitantly, caution and close observation are advised.
- Zhou-Pan XR, Seree E, Zhou XJ, et al "Involvement of human liver cytochrome P450 3A in vinblastine metabolism: drug interactions." Cancer Res 53 (1993): 5121-6
- "Product Information. Oncovin (vincristine)." Lilly, Eli and Company, Indianapolis, IN.
Generic Name: fluorouracil
Brand name: Adrucil
Synonyms: Adrucil (injection), Adrucil
Generic Name: vincristine
Brand name: Oncovin, Vincasar PFS
Synonyms: VinCRIStine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Adrucil injection-Vincristine (Liposomal)
- Adrucil injection-Vincristine Intravenous
- Adrucil injection-Vincristine liposome
- Adrucil injection-Vincristine liposome Intravenous
- Adrucil injection-Vincristine Sulfate
- Adrucil injection-Vinorelbine
- Vincristine-Advair
- Vincristine-Advair Diskus
- Vincristine-Advair Diskus 100/50
- Vincristine-Advair Diskus 250/50
- Vincristine-Advair Diskus 500/50
- Vincristine-Advair HFA