Advair Diskus 250/50 and Phenylephrine Hydrochloride
Determining the interaction of Advair Diskus 250/50 and Phenylephrine Hydrochloride and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using phenylephrine together with salmeterol may increase cardiovascular side effects such as elevations in heart rate and blood pressure or irregular heart rhythm. Talk to your doctor if you have any questions or concerns, particularly if you have a history of high blood pressure, arrhythmia, or heart disease. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration of beta-2 adrenergic agonists with other adrenergic agents may potentiate the risk of cardiovascular side effects. Beta-2 adrenergic agonists can produce clinically significant cardiovascular effects including increases in pulse rate and systolic or diastolic blood pressure as well as ECG changes such as flattening of the T wave, prolongation of the QTc interval, and ST segment depression. The risk is lower when beta-2 adrenergic agonists are inhaled at normally recommended dosages. However, these effects may be more common when the drugs are administered systemically or when recommended dosages are exceeded.
MANAGEMENT: Caution is advised if beta-2 adrenergic agonists are used concomitantly with other adrenergic agents, particularly in patients with cardiovascular disorders such as coronary insufficiency, cardiac arrhythmias, hypertrophic obstructive cardiomyopathy, or hypertension. Blood pressure and heart rate should be closely monitored.
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Generic Name: fluticasone / salmeterol
Brand name: Advair Diskus, Advair HFA, AirDuo RespiClick, Wixela Inhub
Synonyms: Advair
Generic Name: phenylephrine
Brand name: Nasop, Sudafed PE, Sudogest PE, Neo-Synephrine, Ah-Chew D, Despec-SF, Lusonal, Sudafed PE Quick Dissolve, Sudafed PE Extra Strength, Triaminic Thin Strips Nasal Congestion, Triaminic Toddler Congestion Thin Strips, Nasop12, Dimetapp Cold Drops, Triaminic Thin Strips Cold, Triaminic Thin Strips Infant Decongestant, Dimetapp Children's Cold & Allergy, Phenyl-T, PediaCare Children's Decongestant, Sudafed PE Children's Nasal Decongestant, Vazculep, Sudafed PE Congestion, Contac-D
Synonyms: Phenylephrine, Phenylephrine (Systemic)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Advair Diskus 250/50-Phenylephrine Hydrochloride Injection
- Advair Diskus 250/50-Phenylephrine Injection
- Advair Diskus 250/50-Phenylephrine Intravenous
- Advair Diskus 250/50-Phenylephrine Liquid
- Advair Diskus 250/50-Phenylephrine nasal
- Advair Diskus 250/50-Phenylephrine ophthalmic
- Phenylephrine Hydrochloride-Advair Diskus 500/50
- Phenylephrine Hydrochloride-Advair HFA
- Phenylephrine Hydrochloride-Advair HFA 115/21
- Phenylephrine Hydrochloride-Advair HFA 230/21
- Phenylephrine Hydrochloride-Advair HFA 45/21
- Phenylephrine Hydrochloride-Advair HFA Inhaler