Advil Childrens Allergy Sinus and Fedratinib
Determining the interaction of Advil Childrens Allergy Sinus and Fedratinib and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this interaction is not currently available.MONITOR: Coadministration of fedratinib may increase the plasma concentrations of drugs that are substrates of CYP450 3A4, 2C19, or 2D6 isoenzymes. Coadministration of fedratinib with a single dose each of the CYP450 3A4 substrate midazolam (2 mg), CYP450 2C19 substrate omeprazole (20 mg), and CYP450 2D6 substrate metoprolol (100 mg) increased the systemic exposure (AUC) of the substrates by 4-, 3-, and 2-fold, respectively. MANAGEMENT: Caution is recommended when fedratinib is used concomitantly with substrates of CYP450 3A4, 2C19, or 2D6. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever fedratinib is added to or withdrawn from therapy, particularly those with a narrow therapeutic index. References "Product Information. Inrebic (fedratinib)." Celgene Corporation, Summit, NJ.
Professional:MONITOR: Coadministration of fedratinib may increase the plasma concentrations of drugs that are substrates of CYP450 3A4, 2C19, or 2D6 isoenzymes. Coadministration of fedratinib with a single dose each of the CYP450 3A4 substrate midazolam (2 mg), CYP450 2C19 substrate omeprazole (20 mg), and CYP450 2D6 substrate metoprolol (100 mg) increased the systemic exposure (AUC) of the substrates by 4-, 3-, and 2-fold, respectively.
MANAGEMENT: Caution is recommended when fedratinib is used concomitantly with substrates of CYP450 3A4, 2C19, or 2D6. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever fedratinib is added to or withdrawn from therapy, particularly those with a narrow therapeutic index.
- "Product Information. Inrebic (fedratinib)." Celgene Corporation, Summit, NJ.
Generic Name: chlorpheniramine / ibuprofen / pseudoephedrine
Brand name: Advil Allergy Sinus, Advil Childrens Allergy Sinus, Advil Multi-Symptom Cold
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Advil Childrens Allergy Sinus-Fedratinib Hydrochloride
- Advil Childrens Allergy Sinus-Feiba
- Advil Childrens Allergy Sinus-Feiba NF
- Advil Childrens Allergy Sinus-Feiba VH Immuno
- Advil Childrens Allergy Sinus-Feiba-VH
- Advil Childrens Allergy Sinus-Felbamate
- Fedratinib-Advil Childrens Cold
- Fedratinib-Advil Cold & Sinus
- Fedratinib-Advil Cold and Sinus Caplets
- Fedratinib-Advil Cold and Sinus Liqui-Gel
- Fedratinib-Advil Cold and Sinus Liqui-Gels
- Fedratinib-Advil Congestion Relief