Advil Childrens Cold and Valproic acid
Determining the interaction of Advil Childrens Cold and Valproic acid and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:High doses of ibuprofen (greater than 400 mg/day) may displace valproic acid from protein binding sites in vitro. This interaction may be more significant in uremic patients. Free valproic acid concentrations should be measured if toxicity is suspected.
- Dasgupta A, Volk A "Displacement of valproic acid and carbamazepine from protein binding in normal and uremic sera by tolmetin, ibuprofen, and naproxen: presence of inhibitor in uremic serum that blocks valproic acid-naproxen interactions." Ther Drug Monit 18 (1996): 284-7
Generic Name: ibuprofen / pseudoephedrine
Brand name: Advil Cold & Sinus, Advil Cold and Sinus Liqui-Gel, Dimetapp Sinus, Dristan Sinus, Motrin IB Sinus, Sine-Aid IB, Dayquil Pressure and Pain Caplet, Motrin Cold and Flu, Motrin Childrens Cold, Motrin Sinus Headache, Dimetapp Childrens Cold & Fever, Children's Ibuprofen Cold Relief
Synonyms: n.a.
Generic Name: valproic acid
Brand name: Depakene, Depacon, Stavzor, Valproate Sodium
Synonyms: Valproic Acid and Derivatives
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Advil Childrens Cold-Valproic Acid and Derivatives
- Advil Childrens Cold-Valproic Acid Capsules
- Advil Childrens Cold-Valproic Acid Liquid
- Advil Childrens Cold-Valproic Acid Oral Solution
- Advil Childrens Cold-Valproic Acid Syrup
- Advil Childrens Cold-Valrubicin
- Valproic acid-Advil Cold & Sinus
- Valproic acid-Advil Cold and Sinus Caplets
- Valproic acid-Advil Cold and Sinus Liqui-Gel
- Valproic acid-Advil Cold and Sinus Liqui-Gels
- Valproic acid-Advil Congestion Relief
- Valproic acid-Advil Infants Concentrated Drops