Advil Cold & Sinus and Depakene
Determining the interaction of Advil Cold & Sinus and Depakene and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:High doses of ibuprofen (greater than 400 mg/day) may displace valproic acid from protein binding sites in vitro. This interaction may be more significant in uremic patients. Free valproic acid concentrations should be measured if toxicity is suspected.
- Dasgupta A, Volk A "Displacement of valproic acid and carbamazepine from protein binding in normal and uremic sera by tolmetin, ibuprofen, and naproxen: presence of inhibitor in uremic serum that blocks valproic acid-naproxen interactions." Ther Drug Monit 18 (1996): 284-7
Generic Name: ibuprofen / pseudoephedrine
Brand name: Advil Cold & Sinus, Advil Cold and Sinus Liqui-Gel, Dimetapp Sinus, Dristan Sinus, Motrin IB Sinus, Sine-Aid IB, Dayquil Pressure and Pain Caplet, Motrin Cold and Flu, Motrin Childrens Cold, Motrin Sinus Headache, Dimetapp Childrens Cold & Fever, Children's Ibuprofen Cold Relief
Synonyms: Advil Cold and Sinus
Generic Name: valproic acid
Brand name: Depakene, Depacon, Stavzor, Valproate Sodium
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Advil Cold & Sinus-Depakene (Valproic Acid Capsules)
- Advil Cold & Sinus-Depakene (Valproic Acid Liquid)
- Advil Cold & Sinus-Depakote
- Advil Cold & Sinus-Depakote (Divalproex Long-Acting Tablets)
- Advil Cold & Sinus-Depakote (Divalproex Sprinkle Capsules)
- Advil Cold & Sinus-Depakote Capsules
- Depakene-Advil Cold and Sinus Caplets
- Depakene-Advil Cold and Sinus Liqui-Gel
- Depakene-Advil Cold and Sinus Liqui-Gels
- Depakene-Advil Congestion Relief
- Depakene-Advil Infants Concentrated Drops
- Depakene-Advil Liqui-Gels