Advil PM and Busulfan

• Generic Name: diphenhydramine / ibuprofen
• Dosage Forms: tablet, coated
• Other Brand Names: Advil PM, Advil PM Liqui-Gels, Ibuprofen PM, Motrin PM

Diphenhydramine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose. Antihistamines can cause drowsiness, which can aid in the treatment of occasional sleep problems (insomnia).

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). Ibuprofen works by reducing hormones that cause inflammation and pain in the body.

Advil PM is a combination medicine used to treat occasional insomnia associated with minor aches and pains.

Advil PM is not for use in treating sleeplessness without pain, or sleep problems that occur often.

Advil PM may also be used for purposes not listed in this medication guide.

• Generic Name: busulfan
• Dosage Forms: n.a.
• Other Brand Names: Busulfex, Myleran

Used IV in combination with cyclophosphamide: as a conditioning regimen prior to allogeneic hematopoietic progenitor cell transplantation in patients with chronic myelogenous leukemia (CML) (designated an orphan drug by US FDA for this use).

Also administered orally as a component of a conditioning regimen prior to allogeneic transplantation.

Rarely, used as an alternative agent for palliative treatment of CML. Not curative, but approximately 90% of patients in the chronic phase of CML treated with the drug obtain remissions.

Component of pretransplant conditioning regimens in patients undergoing bone marrow transplantation for acute myeloid leukemia and nonmalignant diseases (e.g., sickle cell disease).