Advil PM and Polatuzumab Vedotin-piiq

• Generic Name: diphenhydramine / ibuprofen
• Dosage Forms: tablet, coated
• Other Brand Names: Advil PM, Advil PM Liqui-Gels, Ibuprofen PM, Motrin PM

Diphenhydramine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose. Antihistamines can cause drowsiness, which can aid in the treatment of occasional sleep problems (insomnia).

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). Ibuprofen works by reducing hormones that cause inflammation and pain in the body.

Advil PM is a combination medicine used to treat occasional insomnia associated with minor aches and pains.

Advil PM is not for use in treating sleeplessness without pain, or sleep problems that occur often.

Advil PM may also be used for purposes not listed in this medication guide.

• Generic Name: polatuzumab vedotin
• Dosage Forms: n.a.
• Other Brand Names: Polivy

Polatuzumab vedotin-piiq is a CD79b-directed antibody–drug conjugate indicated in combination with bendamustine and a rituximab product for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma, not otherwise specified, after at least two prior therapies.

Accelerated approval was granted for this indication based on complete response rate. Continued approval for this indication may be contingent upon verification and description of clinical benefit in a confirmatory trial.