Afinitor and Fedratinib

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this interaction is not currently available.GENERALLY AVOID: Coadministration with potent or moderate inhibitors of CYP450 3A4 and/or P-glycoprotein may significantly increase the plasma concentrations of everolimus following oral administration. Everolimus is a substrate of both the CYP450 3A4 isoenzyme and P-glycoprotein drug efflux transporter, thus their inhibition in the intestine can enhance the absorption of everolimus. The risk of side effects such as pneumonitis, stomatitis, infection, dyspnea, diarrhea, anemia, leucopenia, thrombocytopenia, hyperglycemia, and hyperlipidemia may be increased. MANAGEMENT: The use of everolimus with potent or moderate inhibitors of CYP450 3A4 and/or P-glycoprotein such as protease inhibitors, macrolide antibiotics, and azole antifungal agents should generally be avoided. References "Product Information. Afinitor (everolimus)." Novartis Pharmaceuticals, East Hanover, NJ.

GENERALLY AVOID: Coadministration with potent or moderate inhibitors of CYP450 3A4 and/or P-glycoprotein may significantly increase the plasma concentrations of everolimus following oral administration. Everolimus is a substrate of both the CYP450 3A4 isoenzyme and P-glycoprotein drug efflux transporter, thus their inhibition in the intestine can enhance the absorption of everolimus. The risk of side effects such as pneumonitis, stomatitis, infection, dyspnea, diarrhea, anemia, leucopenia, thrombocytopenia, hyperglycemia, and hyperlipidemia may be increased.

MANAGEMENT: The use of everolimus with potent or moderate inhibitors of CYP450 3A4 and/or P-glycoprotein such as protease inhibitors, macrolide antibiotics, and azole antifungal agents should generally be avoided.

Afinitor

Generic Name: everolimus

Brand name: Afinitor, Afinitor Disperz, Zortress

Synonyms: n.a.

What is Afinitor?

Fedratinib

Generic Name: fedratinib

Brand name: Inrebic

Synonyms: n.a.

What is Fedratinib?