Afinitor and Miconazole Buccal mucosa
Determining the interaction of Afinitor and Miconazole Buccal mucosa and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Miconazole may increase the blood levels and effects of everolimus. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with miconazole may increase the plasma concentrations of drugs that are substrates of CYP450 3A4. The mechanism is decreased clearance due to inhibition of CYP450 3A4 activity by miconazole, which is thought to be a relatively potent inhibitor of the isoenzyme. No formal drug interaction studies have been conducted with miconazole buccal tablets. Although systemic absorption following mucous membrane exposure is limited, the potential for interaction with drugs metabolized by CYP450 3A4 cannot be ruled out.
MANAGEMENT: Caution is advised if miconazole must be used concurrently with medications that undergo metabolism by CYP450 3A4, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever miconazole is added to or withdrawn from therapy.
- "Product Information. ORAVIG (miconazole)." Strativa Pharmaceuticals, a Division of Par Pharmaceuticals, Inc., Woodcliff Lake, NJ.
Generic Name: everolimus
Brand name: Afinitor, Afinitor Disperz, Zortress
Synonyms: n.a.
Generic Name: miconazole
Brand name: Oravig, Monistat IV, Oravig
Synonyms: Miconazole oral (buccal), Miconazole (Oral)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Afinitor-Miconazole Cream and Ointment
- Afinitor-Miconazole Liquid
- Afinitor-Miconazole Nitrate
- Afinitor-Miconazole oral buccal
- Afinitor-Miconazole Powder
- Afinitor-Miconazole Spray and Spray Powder
- Miconazole Buccal mucosa-Afinitor Disperz
- Miconazole Buccal mucosa-Afirmelle
- Miconazole Buccal mucosa-Aflaxen
- Miconazole Buccal mucosa-Aflexeryl-MC
- Miconazole Buccal mucosa-Afluria
- Miconazole Buccal mucosa-Afluria 2015-2016 Formula