Afinitor and Safinamide Mesylate

• Generic Name: everolimus
• Dosage Forms: tablet, tablet for oral suspension
• Other Brand Names: Afinitor, Afinitor Disperz, Zortress

Afinitor (everolimus) is a cancer medicine that interferes with the growth of cancer cells and slows their spread in the body.

Afinitor is used to treat certain types of kidney cancer, breast cancer, or brain tumor. It is also used to treat certain types of advanced or progressive tumors of the stomach, intestines, or pancreas.

Afinitor is also used to treat certain types of seizures or non-cancerous (benign) tumors of the brain or kidney in people with a genetic condition called tuberous sclerosis complex.

This medication guide provides information about the Afinitor brand of everolimus. Zortress is another brand of everolimus used to prevent organ rejection after a kidney transplant.

• Generic Name: safinamide
• Dosage Forms: n.a.
• Other Brand Names: Xadago

Used as an adjunct to levodopa-carbidopa for the symptomatic treatment of parkinsonian syndrome (e.g., parkinsonism, Parkinson disease [paralysis agitans]) in patients who experience “off” episodes (i.e., time when drug effect wears off and parkinsonian manifestations return).

Shown to be effective only in combination with levodopa-carbidopa; efficacy of safinamide monotherapy not established.