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Agenerase and Caltrate 600+D Soft Chews

Determining the interaction of Agenerase and Caltrate 600+D Soft Chews and the possibility of their joint administration.

Check result:

Agenerase <> Caltrate 600+D Soft Chews

Relevance: 05.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using calcium carbonate together with amprenavir may decrease the effects of amprenavir. Amprenavir should be administered at least 1 hour before or after calcium carbonate. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADJUST DOSING INTERVAL: Concurrent administration of antacids or other agents with acid-neutralizing effects may decrease the oral bioavailability of amprenavir and reduce its concentrations in plasma. Amprenavir solubility decreases with increasing pH, thus reduction in gastric acidity may interfere with dissolution of the drug. Subtherapeutic antiretroviral drug levels may lead to reduced viral susceptibility and development of resistance. In contrast, the prodrug fosamprenavir appears to be less affected by antacids. Administration of a single 1400 mg dose with 30 mL of antacid (Maalox TC) resulted in decreased peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of amprenavir by 35% and 18%, respectively. However, trough plasma concentration (Cmin) increased by 14%.

MANAGEMENT: Amprenavir should be administered at least 1 hour before or after antacids or other oral preparations containing antacids (e.g., didanosine buffered tablets or pediatric oral solution).

References

"Product Information. Agenerase (amprenavir)." Glaxo Wellcome, Research Triangle Pk, NC.
"Product Information. Lexiva (fosamprenavir)." GlaxoSmithKline, Research Triangle Park, NC.

Agenerase

Generic Name: amprenavir

Brand name:

Synonyms: n.a.

What is Agenerase?

Caltrate 600+D Soft Chews

Generic Name: calcium / vitamin d

Brand name: Calcitrate with D, Caltrate 600+D Soft Chews, Citracal + D, Os-Cal Extra D3, Oystercal-D, UpCal D, Os-Cal 250 with D, Oysco D, Dical-D, Calcet, Oyster Shell Calcium with Vitamin D, O-Cal-D, Oyster-D, Oyst-Cal-D, Caltro with Vitamin D, Oysco 500 with D, Oysco D with Calcium, Os-Cal with D, Caltrate 600 with D, Calcarb with D, Posture-D H/P, Dical Captabs, Dicalphos plus D, Os-Cal 500 with D, Caltrate 600 with D Plus Soy, Caltrate Colon Health, Calvite P & D, Sedecal D, Chewable Calcium with Vitamin D, Osteocit D Plus, Os-Cal 500 + D, Citracal Petites, Citracal Creamy Bites, Citracal 250 mg + D, Calcio Del Mar, Citrus Calcium with Vitamin D, Calcium 600+D, Risacal-D, Liquid Calcium with Vitamin D, Citracal Maximum + D, Citracal Calcium + D Slow Release 1200, Citracal Calcium Gummies, Caltrate Gummy Bites, Super Calcium 600 + D3 400, Os-Cal Calcium+D3, Caltrate 600 + D, Citracal Regular, Calcet Petites, Calcium 500+D, D3 with Calcium, Calcitrate, Caltrate 600+D, Os-Cal 500+D, Os-Cal 500+Extra D Chewable

Synonyms: n.a.

What is Caltrate 600+D Soft Chews?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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