Agenerase and Cardioquin

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Talk to your doctor before using quiNIDine together with amprenavir. Combining these medications may significantly increase the blood levels of quiNIDine. This can increase the risk of serious side effects such as irregular heart rhythm and other cardiovascular problems. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR CLOSELY: Coadministration with amprenavir or its prodrug, fosamprenavir, may significantly increase the plasma concentrations of antiarrhythmic agents that are primarily metabolized by CYP450 3A4 such as amiodarone, bepridil, systemic lidocaine, and quinidine. The proposed mechanism is decreased clearance due to inhibition of CYP450 3A4 activity by amprenavir. The interaction has not been specifically studied, but could conceivably lead to serious and/or life-threatening reactions including cardiac arrhythmias and other toxicities if levels are substantially increased. The use of amiodarone, bepridil, and quinidine has been associated with dose-related prolongation of the QT interval, thus elevated plasma levels may potentiate the risk of ventricular arrhythmias such as ventricular tachycardia and torsade de pointes as well as cardiac arrest and sudden death.

MANAGEMENT: Caution is advised if amprenavir or fosamprenavir must be used with antiarrhythmic agents that are substrates of CYP450 3A4. Pharmacologic response and plasma antiarrhythmic drug levels should be monitored more closely whenever amprenavir or fosamprenavir is added to or withdrawn from therapy, and the antiarrhythmic dosage adjusted as necessary. Concomitant use with amiodarone, bepridil, lidocaine, or quinidine is specifically contraindicated according to Canadian and European labeling.

Agenerase

Generic Name: amprenavir

Brand name:

Synonyms: n.a.

What is Agenerase?

Cardioquin

Generic Name: quinidine

Brand name: Quin-G, Cardioquin, Quinora, Quinidex Extentabs, Quinaglute Dura-Tabs, Quin-Release

Synonyms: n.a.

What is Cardioquin?