Agenerase and Etravirine

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Ask your doctor before using amprenavir together with etravirine. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Coadministration of etravirine and protease inhibitors without concomitant ritonavir as a pharmacokinetic booster may produce significant alterations in plasma concentrations of the protease inhibitor. Etravirine is an inducer of CYP450 3A4 and inhibitor of CYP450 2C19 and 2C9, thus it may variously affect the metabolism and clearance of protease inhibitors. In unboosted pharmacokinetic regimens, etravirine has reduced plasma levels of atazanavir and indinavir and increased levels of amprenavir and nelfinavir. However, significant interactions affecting either etravirine and/or protease inhibitor plasma concentrations have also been observed with boosted regimens, including atazanavir/ritonavir, fosamprenavir/ritonavir, and tipranavir/ritonavir.

MANAGEMENT: Protease inhibitors should not be prescribed with etravirine in the absence of low-dose ritonavir as a pharmacokinetic booster.

Agenerase

Generic Name: amprenavir

Brand name:

Synonyms: n.a.

What is Agenerase?

Etravirine

Generic Name: etravirine

Brand name: Intelence

Synonyms: n.a.

What is Etravirine?