Agenerase and Methadone Injection Solution

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Ask your doctor before using methadone together with amprenavir. Using these medications together may cause either drug to be less effective. Alternative antiretroviral therapy should be considered if you receive treatment with methadone. Contact your doctor if your condition worsens or if you experience restlessness, trouble sleeping, sweating, or a runny nose or watery eyes. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Coadministration of amprenavir and methadone may result in decreased plasma concentrations of both drugs. The exact mechanism of interaction has not been described. In 16 subjects treated with methadone (44 to 100 mg daily for at least 30 days) and amprenavir (1200 mg twice a day for 10 days), mean peak plasma concentration (Cmax), systemic exposure (AUC) and trough plasma concentration (Cmin) of the active R(+) enantiomer of methadone were reduced by 25%, 13% and 21%, respectively, compared to administration of methadone alone. The combination was also associated with a 27%, 30% and 25% decrease in serum amprenavir Cmax, AUC and Cmin, respectively, compared to a non-matched historical control group.

MANAGEMENT: Given the risk of reduced viral susceptibility and resistance development associated with subtherapeutic antiretroviral drug levels, alternative antiretroviral therapy should be considered in patients treated with methadone. Patients who are prescribed the combination should be monitored for potentially reduced antiretroviral response and opiate withdrawal symptoms. Patients should be advised to notify their caregiver if they experience symptoms of methadone withdrawal such as restlessness, insomnia, sweating, lacrimation, or rhinorrhea.

Agenerase

Generic Name: amprenavir

Brand name:

Synonyms: n.a.

What is Agenerase?

Methadone Injection Solution

Generic Name: methadone

Brand name: Dolophine, Methadose, Methadose Sugar-Free, Diskets

Synonyms: Methadone

What is Methadone Injection Solution?