Agenerase and Norvir Tablets

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using amprenavir together with ritonavir may increase the effects of amprenavir. Contact your doctor if you experience increased side effects or if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSE: The concomitant administration of ritonavir may significantly increase amprenavir AUC and trough concentrations. In healthy subjects, amprenavir AUC increased by 62% to 64% and trough concentrations increased by 319% to 508% with ritonavir 200 mg/day. The mechanism is inhibition of CYP450 3A4 metabolism by ritonavir.

MANAGEMENT: The manufacturer recommends that the adult amprenavir dosage be reduced to 1200 mg once daily with ritonavir 200 mg once daily or 600 mg twice daily with ritonavir 100 mg twice daily.

Agenerase

Generic Name: amprenavir

Brand name:

Synonyms: n.a.

What is Agenerase?

Norvir Tablets

Generic Name: ritonavir

Brand name: Norvir, Norvir Soft Gelatin

Synonyms: Ritonavir

What is Norvir Tablets?