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Agenerase and Zidovudine Capsules and Tablets

Determining the interaction of Agenerase and Zidovudine Capsules and Tablets and the possibility of their joint administration.

Check result:
Agenerase <> Zidovudine Capsules and Tablets
Relevance: 05.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Coadministration of amprenavir with zidovudine may result in increased blood levels of zidovudine. Average zidovudine levels increased 13% (range: 2% decrease to 31% increase) in the area under the time concentration curve during concurrent administration. The clinical significance is unknown. Patients should be monitored for altered efficacy and safety during concurrent use. Dose reductions may be required if significant anemia occurs.

References
  • "Product Information. Agenerase (amprenavir)." Glaxo Wellcome, Research Triangle Pk, NC.
Agenerase

Generic Name: amprenavir

Brand name:

Synonyms: n.a.

Zidovudine Capsules and Tablets

Generic Name: zidovudine

Brand name: Retrovir

Synonyms: Zidovudine (oral/injection), Zidovudine

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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