Aggrastat and Anagrelide

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using tirofiban together with anagrelide can cause you to bleed more easily. You may need a dose adjustment in addition to special testing of your blood. Call your doctor promptly if you have any unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR CLOSELY: The combination of glycoprotein IIb/IIIa inhibitors and anagrelide can theoretically significantly increase the risk of bleeding. GP IIb/IIIa inhibitors inhibit platelet aggregation by blocking the fibrinogen, von Willebrand factor, and other adhesive ligands to platelets. The mechanism whereby anagrelide decreases platelet concentrations is not known. The combination of these drugs, therefore, could decrease platelet number and function.

MANAGEMENT: Extraordinary precautions are recommended if these drugs must be used together, including monitoring platelet counts and hemoglobin concentrations. In addition, invasive procedures, such as urinary catheterization, nasogastric or nasotracheal intubation, and even venous punctures should be avoided or minimized. Non-compressible venous access sites, such as jugular or subclavian sites, should be avoided.

Aggrastat

Generic Name: tirofiban

Brand name: Aggrastat

Synonyms: n.a.

What is Aggrastat?

Anagrelide

Generic Name: anagrelide

Brand name: Agrylin

Synonyms: n.a.

What is Anagrelide?