Akynzeo (Fosnetupitant and Palonosetron) and Mirabegron
Determining the interaction of Akynzeo (Fosnetupitant and Palonosetron) and Mirabegron and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of mirabegron, which has been shown in vitro to be a substrate of the isoenzyme. However, in vivo results indicate that CYP450 3A4 may play a limited role in the overall elimination. In a study consisting of 23 healthy male and female subjects, mirabegron peak plasma concentration (Cmax) increased by 45% and systemic exposure (AUC) increased by 80% when a single 100 mg dose of mirabegron was administered following multiple dosing of ketoconazole 400 mg daily for 9 days. No dosage adjustment is recommended when mirabegron is administered in combination with ketoconazole and probably other CYP450 3A4 inhibitors.
- "Product Information. Myrbetriq (mirabegron)." Astellas Pharma US, Inc, Deerfield, IL.
Generic Name: fosnetupitant / palonosetron
Brand name: Akynzeo for injection
Synonyms: Fosnetupitant and palonosetron (injection), Fosnetupitant and Palonosetron
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Akynzeo (Fosnetupitant and Palonosetron)-Miradyne-3
- Akynzeo (Fosnetupitant and Palonosetron)-MiraLAX
- Akynzeo (Fosnetupitant and Palonosetron)-Miranel AF (Miconazole (Vaginal))
- Akynzeo (Fosnetupitant and Palonosetron)-Miranel AF (Miconazole Liquid)
- Akynzeo (Fosnetupitant and Palonosetron)-Mirapex
- Akynzeo (Fosnetupitant and Palonosetron)-Mirapex ER
- Mirabegron-Akynzeo (Netupitant and Palonosetron)
- Mirabegron-Akynzeo for injection
- Mirabegron-Akynzeo Intravenous
- Mirabegron-Ala Hist IR
- Mirabegron-Ala Hist PE
- Mirabegron-Ala Quin Cream