Akynzeo (Netupitant and Palonosetron) and Armodafinil
Determining the interaction of Akynzeo (Netupitant and Palonosetron) and Armodafinil and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of modafinil (the racemate) and armodafinil (the R-enantiomer), which are both partially metabolized by the isoenzyme. Conversely, the plasma levels of some of these inhibitors may decrease, since many of them are also substrates of CYP450 3A4, and modafinil and armodafinil have been found to be modest inducers of CYP450 3A4. The clinical significance of this potential interaction is unknown. Clinical monitoring for altered effects of modafinil and armodafinil as well as the CYP450 3A4 inhibitor may be appropriate following addition or withdrawal of one or the other drug. Dose adjustments may be required if an interaction is suspected.
- "Product Information. Provigil (modafinil)." Cephalon, Inc, West Chester, PA.
- Cerner Multum, Inc. "Australian Product Information." O 0
- "Product Information. Nuvigil (armodafinil)." Cephalon Inc, West Chester, PA.
Generic Name: netupitant / palonosetron
Brand name: Akynzeo
Synonyms: Akynzeo
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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- Armodafinil-Akynzeo for injection
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