Akynzeo (Netupitant and Palonosetron) and Busulfan

• Generic Name: netupitant / palonosetron
• Dosage Forms: capsule
• Other Brand Names: Akynzeo

• It is used to treat or prevent upset stomach and throwing up.

• Generic Name: busulfan
• Dosage Forms: n.a.
• Other Brand Names: Busulfex, Myleran

Used IV in combination with cyclophosphamide: as a conditioning regimen prior to allogeneic hematopoietic progenitor cell transplantation in patients with chronic myelogenous leukemia (CML) (designated an orphan drug by US FDA for this use).

Also administered orally as a component of a conditioning regimen prior to allogeneic transplantation.

Rarely, used as an alternative agent for palliative treatment of CML. Not curative, but approximately 90% of patients in the chronic phase of CML treated with the drug obtain remissions.

Component of pretransplant conditioning regimens in patients undergoing bone marrow transplantation for acute myeloid leukemia and nonmalignant diseases (e.g., sickle cell disease).