Alagesic LQ and Hydroxyprogesterone Caproate Injection (Makena)
Determining the interaction of Alagesic LQ and Hydroxyprogesterone Caproate Injection (Makena) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:HYDROXYprogesterone may reduce the blood levels and effects of acetaminophen. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with hydroxyprogesterone may decrease the plasma concentrations of drugs that are metabolized by CYP450 1A2, 2A6, and/or 2B6. An in vitro study using human liver microsomes and CYP isoform-selective substrates indicated that hydroxyprogesterone caproate can increase the metabolic rate of CYP450 1A2, 2A6, and 2B6 by approximately 80%, 150%, and 80%, respectively. The clinical significance has not been determined.
MANAGEMENT: Pharmacologic effects and/or serum concentrations of the coadministered drug should be monitored more closely whenever hydroxyprogesterone is added to or withdrawn from therapy, and the dosage adjusted if an interaction is suspected.
- "Product Information. Makena (hydroxyprogesterone)." Ther-Rx Corporation, Bridgeton, MO.
Generic Name: acetaminophen / butalbital / caffeine
Brand name: Alagesic LQ, Capacet, Esgic, Fioricet, Margesic, Medigesic, Orbivan, Repan, Vanatol LQ, Zebutal, Esgic-Plus, Arcet, Isocet, Pharmagesic, Anoquan, Two-Dyne, Tenake, Anolor 300, Femcet, Geone, Tencet, Triad, Fiorpap, Dolmar, Endolor, Ezol, Ide-cet, G-1, Minotal, Mygracet, Pacaps, Alagesic, Americet, Nonbac, Dolgic LQ, Dolgic Plus, Vanatol S
Synonyms: Alagesic LQ Syrup
Generic Name: hydroxyprogesterone
Brand name: Makena, Makena Auto-Injector, Hylutin, Delta-Lutin, Duralutin, Hyprogesterone, Prodrox
Synonyms: Hydroxyprogesterone injection, Hydroxyprogesterone Caproate
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Alagesic LQ-Hydroxyprogesterone injection
- Alagesic LQ-Hydroxyprogesterone Intramuscular
- Alagesic LQ-Hydroxyquinoline vaginal
- Alagesic LQ-Hydroxyurea
- Alagesic LQ-Hydroxyurea Capsules 200 mg, 300 mg, 400 mg
- Alagesic LQ-Hydroxyurea Capsules 500 mg
- Hydroxyprogesterone Caproate Injection (Makena)-Alagesic LQ Syrup
- Hydroxyprogesterone Caproate Injection (Makena)-Alahist CF
- Hydroxyprogesterone Caproate Injection (Makena)-Alahist DM
- Hydroxyprogesterone Caproate Injection (Makena)-Alahist DM (Brompheniramine, Dextromethorphan, and Phenylephrine)
- Hydroxyprogesterone Caproate Injection (Makena)-Alahist DM (Dexbrompheniramine, Dextromethorphan, and Phenylephrine Liquid)
- Hydroxyprogesterone Caproate Injection (Makena)-Alahist LQ