Alagesic LQ and Isoptin SR
Determining the interaction of Alagesic LQ and Isoptin SR and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Before taking verapamil, tell your doctor if you also use butalbital. You may need dose adjustments or special tests in order to safely take both medications together. You should monitor your blood pressure more closely for changes while taking verapamil whenever butalbital is started or stopped. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.
Professional:MONITOR: Some barbiturates may significantly decrease serum verapamil concentrations and half-life, especially with oral dosage forms. The mechanism is induction of CYP450 3A4 first-pass metabolism of verapamil.
MANAGEMENT: Close observation for reduced verapamil effect is recommended if these drugs must be used together. Dose adjustments may be required. Patients should also be monitored for verapamil toxicity after the barbiturate is discontinued.
- Rutledge DR, Pieper JA, Mirvis DM "Effects of chronic phenobarbital on verapamil dispostion in humans." J Pharmacol Exp Ther 246 (1988): 7-13
Generic Name: acetaminophen / butalbital / caffeine
Brand name: Alagesic LQ, Capacet, Esgic, Fioricet, Margesic, Medigesic, Orbivan, Repan, Vanatol LQ, Zebutal, Esgic-Plus, Arcet, Isocet, Pharmagesic, Anoquan, Two-Dyne, Tenake, Anolor 300, Femcet, Geone, Tencet, Triad, Fiorpap, Dolmar, Endolor, Ezol, Ide-cet, G-1, Minotal, Mygracet, Pacaps, Alagesic, Americet, Nonbac, Dolgic LQ, Dolgic Plus, Vanatol S
Synonyms: Alagesic LQ Syrup
Generic Name: verapamil
Brand name: Calan SR, Isoptin SR, Calan, Verelan, Isoptin, Isoptin IV, Covera-HS, Verelan PM
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Alagesic LQ-Isopto Atropine
- Alagesic LQ-Isopto Atropine Ophthalmic
- Alagesic LQ-Isopto Atropine Ophthalmic Solution
- Alagesic LQ-Isopto Carbachol
- Alagesic LQ-Isopto Carbachol Ophthalmic Solution
- Alagesic LQ-Isopto Carpine
- Isoptin SR-Alagesic LQ Syrup
- Isoptin SR-Alahist CF
- Isoptin SR-Alahist DM
- Isoptin SR-Alahist DM (Brompheniramine, Dextromethorphan, and Phenylephrine)
- Isoptin SR-Alahist DM (Dexbrompheniramine, Dextromethorphan, and Phenylephrine Liquid)
- Isoptin SR-Alahist LQ