Alcohol and Dextrose and Capreomycin Sulfate

• Generic Name: ethanol
• Dosage Forms: injection, solution, injection, USP
• Other Brand Names: Ablysinol

The term "alcohol" has been synonymous with "spirituous" liquids for the past 300 years. The history of alcohol consumption, along with codes limiting its consumption go back to 1700 B.C. There are four types of alcohol: methyl alcohol, ethyl alcohol, propyl alcohol and butyl alcohol. Ethyl Alcohol, or ethanol (C2H5OH), is the type used in the production of alcoholic beverages. The other three types, methyl, propyl and butyl alcohol, if consumed can result in blindness and death, even in relatively small doses.

Alcohol, or ethanol, is the intoxicating agent found in beer, wine and liquor. Alcohol is produced by fermentation of yeast, sugars, and starches.1 Fruits such as grapes, and grains like barley and wheat are most commonly used for wine, beer and liquors. Other plants, such as the cactus or sugar cane may be used in liquor production.

Fourteen grams or about 0.6 fluid ounces of pure alcohol equals one “drink”. Examples of this amount may include one twelve ounce beer (5 percent alcohol), eight to nine ounces of malt liquor (7 percent alcohol), 5 ounces of wine (12 percent alcohol) or 1.5 fluid ounce “shot” of 80 proof liquor (40 percent alcohol).

In the U.S., The Federal Uniform Drinking Age Act, signed into law in 1984 raised the minimum drinking age to 21 years. All states now prohibit the purchase of alcohol by youth under the age of 21 years since 1988. It is illegal to sell or buy alcohol for anyone under the age of 21. According to The Office of the Surgeon General, alcohol is used by more young people in the United States than tobacco or illicit drugs, resulting in a serious public health concern.

• Generic Name: capreomycin
• Dosage Forms: n.a.
• Other Brand Names: Capastat Sulfate

Treatment of active (clinical) tuberculosis (TB) in conjunction with other antituberculosis agents.

Second-line agent used in treatment of drug-resistant TB caused by Mycobacterium tuberculosis known or presumed to be susceptible to capreomycin.

For initial treatment of active TB caused by drug-susceptible M. tuberculosis, recommended multiple-drug regimens consist of an initial intensive phase (2 months) and a continuation phase (4 or 7 months). Although the usual duration of treatment for drug-susceptible pulmonary and extrapulmonary TB (except disseminated infections and TB meningitis) is 6–9 months, ATS, CDC, and IDSA state that completion of treatment is determined more accurately by the total number of doses and should not be based solely on the duration of therapy. A longer duration of treatment (e.g., 12–24 months) usually is necessary for infections caused by drug-resistant M. tuberculosis.

Patients with treatment failure or drug-resistant M. tuberculosis, including multidrug-resistant (MDR) TB (resistant to both isoniazid and rifampin) or extensively drug-resistant (XDR) TB (resistant to both isoniazid and rifampin and also resistant to a fluoroquinolone and at least one parenteral second-line antimycobacterial such as capreomycin, kanamycin, or amikacin), should be referred to or managed in consultation with experts in the treatment of TB as identified by local or state health departments or CDC.