Aldesleukin and Phenylephrine and promethazine
Determining the interaction of Aldesleukin and Phenylephrine and promethazine and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using aldesleukin together with promethazine may increase side effects such as drowsiness, depression, confusion and, rarely, coma. Contact your doctor if you experience excessive tiredness or drowsiness during treatment with aldesleukin. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Sedatives, tranquilizers, muscle relaxants, antidepressants, and other central nervous system (CNS) depressants may have additive CNS-depressant effects with aldesleukin. Aldesleukin has been associated with CNS effects including depression, confusion, and drowsiness, which may progress to coma.
MANAGEMENT: Caution is advised if aldesleukin is used with sedatives, hypnotics, tranquilizers, or other CNS-active medications. Patients should be monitored for CNS depression and other CNS adverse effects. Treatment with aldesleukin should be discontinued if severe lethargy or somnolence develop.
- Agencia EspaƱola de Medicamentos y Productos Sanitarios Healthcare "Centro de informaciĆ³n online de medicamentos de la AEMPS - CIMA. Available from: URL: https://cima.aemps.es/cima/publico/home.html." ([2018]):
- "Product Information. Proleukin (aldesleukin)." Chiron Therapeutics, Emeryville, CA.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Generic Name: phenylephrine / promethazine
Brand name: Phenergan VC, Promethazine VC Plain, Promethazine VC
Synonyms: Promethazine and Phenylephrine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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- Aldesleukin-Phenylephrine Complex
- Aldesleukin-Phenylephrine Eye Drops 10%
- Phenylephrine and promethazine-Aldesleukin Intravenous
- Phenylephrine and promethazine-Aldex G
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- Phenylephrine and promethazine-Aldomet
- Phenylephrine and promethazine-Aldoril
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