Aldurazyme and Clozaril

• Generic Name: laronidase
• Dosage Forms: injection, solution, concentrate
• Other Brand Names: Aldurazyme

Aldurazyme (laronidase) contains an enzyme that occurs naturally in the body in healthy people. Some people lack this enzyme because of a genetic disorder. Laronidase helps replace this missing enzyme in such people.

Aldurazyme is used to treat some of the symptoms of a genetic condition called mucopolysaccharidosis or MPS I, also called Hurler syndrome, Hurler-Scheie syndrome, or Scheie syndrome.

MPS I is a metabolic disorder in which the body lacks the enzyme needed to break down certain substances. These substances can build up in the body, causing enlarged organs, abnormal bone structure, changes in facial features, breathing problems, heart problems, vision or hearing loss, and changes in mental or physical abilities.

Aldurazyme may improve breathing and walking ability in people with this condition. However, this medication is not a cure for MPS I.

• Generic Name: clozapine
• Dosage Forms: tablet
• Other Brand Names: Clozaril, Fazaclo, Versacloz, Clopine, CloZAPine Synthon, Denzapine, Zaponex

Clozaril (clozapine) is an antipsychotic medication. It works by changing the actions of chemicals in the brain.

Clozaril is used to treat severe schizophrenia, or to reduce the risk of suicidal behavior in people with schizophrenia or similar disorders.

Clozaril is available only from a certified pharmacy under a special program.

Clozaril may also be used for indications not mentioned in this review.