Alendronate Oral Solution and Aluminum Hydroxide and Magnesium Carbonate Suspension
Determining the interaction of Alendronate Oral Solution and Aluminum Hydroxide and Magnesium Carbonate Suspension and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Alendronate and aluminum hydroxide should not be taken orally at the same time. Products that contain magnesium, aluminum, calcium, iron, and/or other minerals may interfere with the absorption of alendronate into the bloodstream and reduce its effectiveness. You should take aluminum hydroxide at least 30 minutes after the alendronate dose. Talk to a healthcare professional if you are not sure whether a product contains something that could potentially interact with your medication or if you have questions on how to take this or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:ADJUST DOSING INTERVAL: Products containing aluminum, calcium, magnesium and other polyvalent cations such as antacids or vitamin with mineral supplements are likely to interfere with the gastrointestinal absorption of oral bisphosphonates. For example, the bioavailability of tiludronate has been shown to decrease 80% during simultaneous administration with calcium, and 60% when aluminum- or magnesium-containing antacids were administered one hour before tiludronate.
MANAGEMENT: Antacids or other oral medications containing aluminum, calcium, magnesium and other polyvalent cations should be administered at least 30 minutes after the bisphosphonate dose.
- Darcy PF "Nutrient-drug interactions." Adverse Drug React Toxicol Rev 14 (1995): 233-54
- "Product Information. Boniva (ibandronate)." Roche Laboratories, Nutley, NJ.
- "Product Information. Skelid (tilundronate)." Sanofi Winthrop Pharmaceuticals, New York, NY.
- "Product Information. Bonefos (clodronate)." Rhone-Poulenc Rorer Canada Inc, Laval, QC.
- "Product Information. Actonel (risedronate)." Procter and Gamble Pharmaceuticals, Cincinnati, OH.
- "Product Information. Fosamax (alendronate)." Merck & Co, Inc, West Point, PA.
Generic Name: alendronate
Brand name: Binosto, Fosamax
Synonyms: Alendronate
Generic Name: aluminum hydroxide / magnesium carbonate
Brand name: Gaviscon Extra Relief Formula, Acid Gone, Gaviscon
Synonyms: Aluminum Hydroxide and Magnesium Carbonate Chewable Tablets
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Alendronate Oral Solution-Aluminum Hydroxide and Magnesium Hydroxide Chewable Tablets
- Alendronate Oral Solution-Aluminum Hydroxide and Magnesium Hydroxide Suspension
- Alendronate Oral Solution-Aluminum Hydroxide and Magnesium Trisilicate
- Alendronate Oral Solution-Aluminum hydroxide, magnesium hydroxide, and simethicone
- Alendronate Oral Solution-Aluminum Hydroxide, Magnesium Hydroxide, and Simethicone Chewable Tablets
- Alendronate Oral Solution-Aluminum Hydroxide, Magnesium Hydroxide, and Simethicone Suspension
- Aluminum Hydroxide and Magnesium Carbonate Suspension-Alendronate Sodium
- Aluminum Hydroxide and Magnesium Carbonate Suspension-Alendronate Tablets
- Aluminum Hydroxide and Magnesium Carbonate Suspension-Alesse
- Aluminum Hydroxide and Magnesium Carbonate Suspension-Alesse Oral
- Aluminum Hydroxide and Magnesium Carbonate Suspension-Alesse-28 Oral
- Aluminum Hydroxide and Magnesium Carbonate Suspension-Aleve