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Alfentanil and Scandonest 3% Plain

Determining the interaction of Alfentanil and Scandonest 3% Plain and the possibility of their joint administration.

Check result:

Alfentanil <> Scandonest 3% Plain

Relevance: 15.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Concomitant use of lidocaine theoretically may decrease the clearance and increase the elimination half-life of alfentanil. The mechanism is thought to be inhibition of the cytochrome P-450 isoenzyme 3A3/4. If lidocaine is used in a patient who has been receiving alfentanil for an extended period of time, the patient should be monitored more closely for excessive alfentanil effects (i.e., central nervous system depression, respiratory depression). Other amide-type local anesthetics may interact with alfentanil in a similar manner.

References

Yun CH, Wood M, Wood AJ, Guengerich FP "Identification of the pharmacogenetic determinants of alfentanil metabolism: cytochrome P-450 3A4: an explanation of the variable elimination clearance." Anesthesiology 77 (1992): 467-74
Koehntop DE, Noormohamed SE, Fletcher CV "Effects of long-term drugs on alfentanil clearance in patients undergoing renal transplantation." Pharmacotherapy 14 (1994): 592-9
Kharasch ED, Thummel KE "Human alfentanil metabolism by cytochrome P450 3A3/4. An explanation for the interindividual variability in alfentanil clearance?" Anesth Analg 76 (1993): 1033-9

Alfentanil

Generic Name: alfentanil

Brand name:

Synonyms: n.a.

What is Alfentanil?

Scandonest 3% Plain

Generic Name: mepivacaine

Brand name: Carbocaine 2% with Neo-Cobefrin, Polocaine Dental, Scandonest 2% L, Carbocaine, Carbocaine Preservative-Free, Polocaine, Polocaine-MPF, Scandonest 3% Plain, Carbocaine HCl, Scandonest, Polocaine DENTAL

Synonyms: n.a.

What is Scandonest 3% Plain?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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