Drug search by name

Alfentanil Intravenous and Lusedra

Determining the interaction of Alfentanil Intravenous and Lusedra and the possibility of their joint administration.

Check result:

Alfentanil Intravenous <> Lusedra

Relevance: 18.07.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using fospropofol together with alfentanil may have increased effects on breathing, heart rate, blood pressure, and sedation. You will be monitored closely by your surgical team during anesthesia, and the doses of each medication adjusted accordingly. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADJUST DOSE: Additive central nervous system and cardiorespiratory depressant effects may occur when fospropofol or propofol is administered with alfentanil. Also, when combined to provide general anesthesia and analgesia, this combination has demonstrated synergistic activity.

MANAGEMENT: To prevent intraoperative overdose and prolongation of recovery, the dosage of alfentanil given for suppression of surgical stimuli should be reduced when fospropofol or propofol is coadministered. Patients should be monitored closely for excessive sedation and cardiorespiratory depression, and the medication dosage(s) adjusted accordingly. Supportive therapy should be provided if needed.

References

Gill SS, Wright EM, Reilly CS "Pharmacokinetic interaction of propofol and fentanyl: single bolus injection study." Br J Anaesth 65 (1990): 760-5
"Product Information. Lusedra (fospropofol)." Eisai Inc, Teaneck, NJ.
Stanski DR, Shafer SL "Quantifying anesthetic drug interaction. Implications for drug dosing." Anesthesiology 83 (1995): 1-5
Vuyk J, Lim T, Engbers FH, Burm AG, Vletter AA, Bovill JG "The pharmacodynamic interaction of propofol and alfentanil during lower abdominal surgery in women." Anesthesiology 83 (1995): 8-22
"Product Information. Diprivan (propofol)." Zeneca Pharmaceuticals, Wilmington, DE.
IselinChaves IA, Flaishon R, Sebel PS, Howell S, Gan TJ, Sigl J, Ginsberg B, Glass PSA "The effect of the interaction of propofol and alfentanil on recall, loss of consciousness, and the bispectral index." Anesth Analg 87 (1998): 949-55

Alfentanil Intravenous

Generic Name: alfentanil

Brand name:

Synonyms: Alfentanil (Intravenous)

What is Alfentanil Intravenous?

Lusedra

Generic Name: fospropofol

Brand name:

Synonyms: n.a.

What is Lusedra?

+ Add a drug Remove all

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

The list of popular interactions