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Alferon N and Rubex

Determining the interaction of Alferon N and Rubex and the possibility of their joint administration.

Check result:

Alferon N <> Rubex

Relevance: 21.07.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Human lymphoblastoid interferon has been shown to enhance the antitumor activity of doxorubicin and cyclophosphamide in animal models by delaying the G2 cell division phase and increasing the number of cells in the S phase. The clinical significance of this finding is unknown.

References

Kang Y, Perry RR "Modulatory effects of tamoxifen and recombinant human alpha- interferon on doxorubicin resistance." Cancer Res 53 (1993): 3040-5
Balkwill FR, Mowshowitz S, Seilman SS, et al. "Positive interactions between interferon and chemotherapy due to direct tumor action rather than effects on host drug-metabolizing enzymes." Cancer Res 44 (1984): 5249-55

Alferon N

Generic Name: interferon alfa-n3

Brand name: Alferon N

Synonyms: n.a.

What is Alferon N?

Rubex

Generic Name: doxorubicin

Brand name: Adriamycin, Adriamycin RDF, Rubex, Adriamycin PFS

Synonyms: Doxorubicin, DOXOrubicin (Conventional)

What is Rubex?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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