Alfuzosin and Boceprevir

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using alfuzosin together with boceprevir is not recommended. Combining these medications may significantly increase the blood levels and effects of alfuzosin. This may cause blood pressure to fall excessively and heart rate to increase, especially when you rise from a sitting or lying position. The risk of other side effects such as dizziness, lightheadedness, fainting, headache, flushing, nasal congestion, heart palpitation, and priapism (prolonged and painful erection unrelated to sexual activity) may also increase. Let your doctor know if you develop these symptoms while using alfuzosin and they do not go away on their own or they become troublesome. Avoid driving or operating hazardous machinery until you know how the medication affects you, and use caution when getting up from a sitting or lying position. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

CONTRAINDICATED: Coadministration with boceprevir, a potent inhibitor of CYP450 3A4, may significantly increase the plasma concentrations of alpha 1-adrenergic blockers that are primarily metabolized by the isoenzyme. Severe hypotension and priapism may occur. Although the interaction has not been specifically studied with boceprevir, other potent CYP450 3A4 inhibitors like ketoconazole have been shown to increase the systemic exposure (AUC) to alfuzosin, silodosin and tamsulosin by approximately 3-fold. In one case report, a 44-year-old man with multiple comorbidities including HIV and HCV developed priapism nine days following the initiation of boceprevir. Among the multitude of drugs the patient was receiving, an interaction between boceprevir and doxazosin, tamsulosin, and/or quetiapine resulting in excessive alpha-1 adrenergic blockade was thought to be the probable cause. The patient required a surgically performed distal penile shunt to correct the problem.

MANAGEMENT: Concomitant use of boceprevir with alfuzosin, doxazosin, silodosin, or tamsulosin is considered contraindicated.

Alfuzosin

Generic Name: alfuzosin

Brand name: Uroxatral

Synonyms: n.a.

What is Alfuzosin?

Boceprevir

Generic Name: boceprevir

Brand name: Victrelis

Synonyms: Boceprevir (Oral)

What is Boceprevir?