Alfuzosin Hydrochloride and Tiazac

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using dilTIAZem and alfuzosin together can lower your blood pressure and slow your heart rate. This can cause a slow heartbeat, headaches, dizziness, or feeling like you might pass out. If you take both medications together, tell your doctor if you have any of these symptoms. Avoid driving until you know how the medications will affect you. You may need a dose adjustment or need your blood pressure checked more often if you take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Concomitant administration of diltiazem may increase the plasma concentration of alfuzosin. The mechanism is inhibition of CYP450 3A4 metabolism by diltiazem. Multiple doses of diltiazem 240 mg with alfuzosin 2.5 mg three times daily increased alfuzosin maximum plasma concentrations (Cmax) by 1.5-fold and the area under the concentration-time curve (AUC) 1.3-fold. In addition, the diltiazem Cmax increased 1.4-fold; the mechanism has not been reported. No changes in blood pressure were reported in this study; however, the manufacturer cautions that additive hypotension may occur when alfuzosin is given in combination with antihypertensive agents.

MANAGEMENT: Hemodynamic responses should be monitored during coadministration, especially during the first few weeks of therapy. Patients should be advised to avoid situations where injury could result if syncope occurs (e.g., driving) and to notify their physician if they experience dizziness or syncope.

Alfuzosin Hydrochloride

Generic Name: alfuzosin

Brand name: Uroxatral

Synonyms: Alfuzosin

What is Alfuzosin Hydrochloride?

Tiazac

Generic Name: diltiazem

Brand name: Tiazac Extended Release Capsules, Cardizem, Cartia XT, Dilacor XR, Dilt-CD, Diltia XT, Diltzac, Matzim LA, Taztia XT, Tiazac, Cardizem CD, Dilt-XR, Tiazac, Cardizem LA

Synonyms: n.a.

What is Tiazac?