Alfuzosin Tablets and Risperdal M-Tab

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using risperiDONE and alfuzosin together can lower your blood pressure and affect the rhythm of your heart especially if you have a heart condition. This can cause a slow heartbeat, headaches, dizziness, and fast or irregular heartbeats. If you take both medications together, tell your doctor if you have any of these symptoms. Avoid driving until you know how the medications will affect you. You may need a dose adjustment or need your blood pressure checked more often if you take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Neuroleptic agents may potentiate the hypotensive effect of alfuzosin secondary to their peripheral alpha1-adrenergic blocking activity. Orthostatic hypotension and syncope associated with vasodilation may occur, particularly during the initial dose-titration period of neuroleptic therapy. In addition, alfuzosin may cause modest prolongation of the QT interval. Theoretically, coadministration with other agents that can prolong the QT interval including many neuroleptics may result in elevated risk of ventricular arrhythmias, including ventricular tachycardia and torsade de pointes, because of additive arrhythmogenic potential related to their effects on the QT interval. During a clinical study involving 45 healthy male subjects, average prolongation of QTc interval at peak plasma concentrations was less with single doses of alfuzosin 10 mg than with alfuzosin 40 mg, and both were less than with moxifloxacin 400 mg. Heart rate increased by an average of 5.2 bpm with alfuzosin 10 mg, 5.8 bpm with alfuzosin 40 mg, and 2.8 bpm with moxifloxacin 400 mg.

MANAGEMENT: Close clinical monitoring for adverse effects is recommended during concurrent therapy. A lower starting dosage and slower titration of the neuroleptic agent may be appropriate in patients receiving alfuzosin, especially if they are elderly. Patients should be advised to notify their physician if they experience orthostatic symptoms (dizziness, lightheadedness, syncope), and to seek medical help if they experience palpitations and fast/ or irregular heartbeats.

Alfuzosin Tablets

Generic Name: alfuzosin

Brand name: Uroxatral

Synonyms: Alfuzosin

What is Alfuzosin Tablets?

Risperdal M-Tab

Generic Name: risperidone

Brand name: Risperdal M-Tab, Perseris, Risperdal Consta, Risperdal, Risperdal Consta

Synonyms: n.a.

What is Risperdal M-Tab?