Aliskiren and Amlodipine and Gengraf Capsules

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using aliskiren together with cycloSPORINE is not recommended. Combining these medications can significantly increase the blood levels and effects of aliskiren. This may cause an excessive fall in blood pressure and increase the risk of a condition called hyperkalemia (high blood potassium), which in severe cases can lead to kidney failure, muscle paralysis, irregular heart rhythm, and cardiac arrest. You may be more likely to develop hyperkalemia while taking aliskiren if you are elderly, dehydrated, or have kidney disease, diabetes, or advanced heart failure. Regular or long-term use of nonsteroidal anti-inflammatory drugs such as ibuprofen or naproxen (Aleve) may also increase your risk. It is important that you maintain adequate fluid intake during treatment with aliskiren. In addition, talk to your doctor to see if you should limit consumption of potassium-rich foods such as tomatoes, raisins, figs, potatoes, lima beans, bananas, plantains, papayas, pears, cantaloupes, mangoes, and potassium-containing salt substitutes. You should seek medical attention if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, a weak pulse, or a slow or irregular heartbeat, as these may be symptoms of hyperkalemia. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Coadministration with cyclosporine may significantly increase the plasma concentrations of aliskiren. The proposed mechanism is cyclosporine inhibition of the intestinal efflux of aliskiren via P-glycoprotein. According to the product labeling, coadministration of 200 mg and 600 mg cyclosporine, a highly potent P-glycoprotein inhibitor, with 75 mg aliskiren resulted in an approximately 2.5-fold increase in aliskiren peak plasma concentration (Cmax) and a 5-fold increase in systemic exposure (AUC).

MANAGEMENT: Concomitant use of aliskiren with cyclosporine is not recommended.

Aliskiren and Amlodipine

Generic Name: aliskiren / amlodipine

Brand name: Tekamlo

Synonyms: n.a.

What is Aliskiren and Amlodipine?

Gengraf Capsules

Generic Name: cyclosporine

Brand name: Gengraf, Neoral, Sandimmune, Sandimmune

Synonyms: Gengraf (Capsules, Modified), Gengraf

What is Gengraf Capsules?