Aliskiren Tablets and Klor-Con

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using aliskiren together with potassium chloride may increase potassium levels in the blood. High levels of potassium can develop into a condition known as hyperkalemia, which in severe cases can lead to kidney failure, muscle paralysis, irregular heart rhythm, and cardiac arrest. You may be more likely to develop hyperkalemia while using these medications if you are elderly, dehydrated, or have kidney disease, diabetes, or advanced heart failure. Regular or long-term use of nonsteroidal anti-inflammatory drugs such as ibuprofen or naproxen (Aleve) may also increase your risk. It is important that you maintain adequate fluid intake during treatment with these medications. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. You should seek medical attention if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat, as these may be symptoms of hyperkalemia. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration of aliskiren with potassium-sparing diuretics or potassium salts may increase the risk of hyperkalemia. All drugs inhibiting the renin-angiotensin system (RAS) including aliskiren can increase serum potassium and cause hyperkalemia. Increases in serum potassium to greater than 5.5 mEq/L were infrequent with aliskiren alone (0.9% compared to 0.6% with placebo). However, when used in combination with an ACE inhibitor in a diabetic population, increases in serum potassium were more frequent (5.5%).

MANAGEMENT: Caution is advised if aliskiren is used in combination with potassium-sparing diuretics or potassium salts. Routine monitoring of electrolytes and renal function may be indicated, particularly in patients with renal impairment, diabetes, old age, worsening heart failure, or a risk for dehydration. Patients should be advised to seek medical attention if they experience signs and symptoms of hyperkalemia such as weakness, listlessness, confusion, tingling of the extremities, and irregular heartbeat.

Aliskiren Tablets

Generic Name: aliskiren

Brand name: Tekturna

Synonyms: Aliskiren

What is Aliskiren Tablets?

Klor-Con

Generic Name: potassium chloride

Brand name: Klor-Con, K-Dur, Kal Potassium 99, K-Tab, K-Tabs, Micro-K, Kaon, Rum-K

Synonyms: n.a.

What is Klor-Con?