Alka-Seltzer Plus Cold Formula and Nitroglycerin Lingual Spray
Determining the interaction of Alka-Seltzer Plus Cold Formula and Nitroglycerin Lingual Spray and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Aspirin may enhance the antihypertensive effect of nitroglycerin. The mechanism is unknown but may be mediated though the prostaglandin system. Management consists of monitoring blood pressure during coadministration.
- Weber S, Rey E, Pipeau C, et al "Influence of aspirin on the hemodynamic effects of sublingual nitroglycerin." J Cardiovasc Pharmacol 5 (1983): 874-7
- Rey E, El-Assaf HD, Richard MO, Weber S, Bourdon A, Picard G, Olive G "Pharmacological interaction between nitroglycerin and aspirin after acute and chronic aspirin treatment of healthy subjects." Eur J Clin Pharmacol 25 (1983): 779-82
- Morcillio E, Reid PR, Dubin N, Ghodgaonkar R, Pitt B "Myocardial prostaglandin E release by nitroglycerin and modification by indomethacin." Am J Cardiol 45 (1980): 53-7
- Karlberg KE, Ahlner J, Henriksson P, Torfgard K, Sylven C "Effects of nitroglycerin on platelet aggregation beyond the effects of actylsalicylic acid in healthy subjects." Am J Cardiol 71 (1993): 361-4
Generic Name: aspirin / chlorpheniramine / phenylephrine
Brand name: Alka-Seltzer Plus Cold Formula
Synonyms: n.a.
Generic Name: nitroglycerin
Brand name: Gonitro, Nitrolingual, NitroMist, Nitrostat, Nitro-Time, Gonitro, Minitran, Nitro TD Patch-A, Nitro-Dur, Nitro-Bid, Nitrol Appli-Kit, Rectiv
Synonyms: Nitroglycerin (oral/sublingual), Nitroglycerin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Alka-Seltzer Plus Cold Formula-Nitroglycerin Ointment
- Alka-Seltzer Plus Cold Formula-Nitroglycerin oral/sublingual
- Alka-Seltzer Plus Cold Formula-Nitroglycerin rectal
- Alka-Seltzer Plus Cold Formula-Nitroglycerin Rectal Ointment
- Alka-Seltzer Plus Cold Formula-Nitroglycerin Slocaps
- Alka-Seltzer Plus Cold Formula-Nitroglycerin Spray
- Nitroglycerin Lingual Spray-Alka-Seltzer Plus Cold Liquigel
- Nitroglycerin Lingual Spray-Alka-Seltzer Plus Flu Liquigels
- Nitroglycerin Lingual Spray-Alka-Seltzer Plus Flu/Body
- Nitroglycerin Lingual Spray-Alka-Seltzer Plus Night-Time Cold
- Nitroglycerin Lingual Spray-Alka-Seltzer Plus-D Sinus/Cold
- Nitroglycerin Lingual Spray-Alkeran