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Alka-Seltzer Plus Flu/Body and Phenytoin

Determining the interaction of Alka-Seltzer Plus Flu/Body and Phenytoin and the possibility of their joint administration.

Check result:

Alka-Seltzer Plus Flu/Body <> Phenytoin

Relevance: 20.02.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using acetaminophen together with phenytoin may alter the effects of acetaminophen and cause serious side effects that may affect your liver. Call your doctor immediately if you experience a fever, chills, joint pain or swelling, excessive tiredness or weakness, unusual bleeding or bruising, skin rash or itching, loss of appetite, nausea, vomiting, or yellowing of the skin or the whites of your eyes. If your doctor does prescribe these medications together, you may need a dose adjustment or special tests to safely take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Hydantoins may increase the potential hepatotoxicity of acetaminophen and decrease its pharmacologic effects. The mechanism may be related to induction of acetaminophen metabolism with consequent increase in hepatotoxic metabolites. This interaction is of greatest concern in cases of acetaminophen overdose.

MANAGEMENT: Monitoring of liver function is recommended. Patients should be advised to avoid large doses or prolonged use of acetaminophen.

References

Miners JO, Attwood J, Birkett DJ "Determinants of acetaminophen metabolism: effect of inducers and inhibitors of drug metabolism on acetaminophen's metabolic pathways." Clin Pharmacol Ther 35 (1984): 480-6
Brackett CC, Bloch JD "Phenytoin as a possible cause of acetaminophen hepatotoxicity: Case report and review of the literature." Pharmacotherapy 20 (2000): 229-33
Bivins BA, Rapp RP, Griffen WO Jr, Blouin R, Bustrack J "Dopamine-phenytoin interaction. A cause of hypotension in the critically ill." Arch Surg 113 (1978): 245-9
Lorenzi M, Karam JH, Tsalikian E, Bohannon NV, Gerich JE, Forsham PH "Dopamine during alpha- or beta-adrenergic blockade in man. Hormonal, metabolic, and cardiovascular effects." J Clin Invest 63 (1979): 310-7
Minton NA, Henry JA, Frankel RJ "Fatal paracetamol poisoning in an epileptic." Hum Toxicol 7 (1988): 33-4
Prescott LF, Critchley JA "Drug interactions affecting analgesic toxicity." Am J Med 75 (1983): 113-6

Alka-Seltzer Plus Flu/Body

Generic Name: acetaminophen / dextromethorphan / pseudoephedrine

Brand name: Alka-Seltzer Plus Flu/Body, DayQuil Multi-Symptom Cold/Flu, EQ Daytime Cold/Flu Relief, EQ Flu Relief, EQL Daytime Cold/Flu Relief, Tylenol Flu Maximum Strength, Sudafed Severe Cold, Tylenol Cold and Flu No Drowsiness Powder, Tylenol Cold No Drowsiness, Theraflu No Drowsiness Maximum Strength, Triaminic Sore Throat Formula, Contac Severe Cold and Flu Non Drowsy, Tylenol Cough Liquid with Decongestant, DayQuil, Day Time Multi Symptom, Triaminic Cold and Fever Formula, Sudafed Decongestant Cold and Cough, Tylenol Cold Severe Congestion, Tylenol Infants Cold Plus Cough, Robitussin Honey Flu, Extra Strength Tylenol Flu Daytime, Non-Drowsy Super Strength Contac Complete, Contact Cold and Sore Throat, Tylenol Cold & Flu Severe Day Time, Vicks Dayquil Daytime Cold/Flu, Triaminic Cough & Sore Throat, Theraflu Severe Cold & Congestion Non-Drowsy, Triaminic Softchews Cough & Sore Throat, Day Relief Cold and Flu, Tylenol Cold & Flu Daytime, Tylenol Cold Non-Drowsy Caplets, Tylenol Cold Non-Drowsy Gelcaps, Daytime Cold and Flu Relief, Daytime Non-Drowsy, Theraflu Daytime Severe Cold, Severe Cold Multi-Sympton

Synonyms: n.a.

What is Alka-Seltzer Plus Flu/Body?

Phenytoin

Generic Name: phenytoin

Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt

Synonyms: n.a.

What is Phenytoin?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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