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Alkeran (Melphalan Injection) and Bortezomib Intravenous

Determining the interaction of Alkeran (Melphalan Injection) and Bortezomib Intravenous and the possibility of their joint administration.

Check result:
Alkeran (Melphalan Injection) <> Bortezomib Intravenous
Relevance: 10.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Coadministration of melphalan plus prednisone has been shown to increase bortezomib systemic exposure. However, the interaction is unlikely to be clinically relevant.

References
  • "Product Information. Velcade (bortezomib)." Millennium Pharmaceuticals Inc, Cambridge, MA.
Alkeran (Melphalan Injection)

Generic Name: melphalan

Brand name: Alkeran, Alkeran IV, Evomela

Synonyms: Alkeran (Injection), ALKERAN

Bortezomib Intravenous

Generic Name: bortezomib

Brand name: Velcade

Synonyms: Bortezomib (Intravenous)

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.