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Alkeran (Melphalan Injection) and Cimetidine Tablets

Determining the interaction of Alkeran (Melphalan Injection) and Cimetidine Tablets and the possibility of their joint administration.

Check result:

Alkeran (Melphalan Injection) <> Cimetidine Tablets

Relevance: 10.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

The oral absorption of melphalan may be reduced by concomitant use of cimetidine. The clinical significance of this interaction is unknown.

References

Sviland L, Robinson A, Proctor SJ, Bateman DN "Interaction of cimetidine with oral melphalen: a pharmacokinetic study." Cancer Chemother Pharmacol 20 (1987): 173-5

Alkeran (Melphalan Injection)

Generic Name: melphalan

Brand name: Alkeran, Alkeran IV, Evomela

Synonyms: Alkeran (Injection), ALKERAN

What is Alkeran (Melphalan Injection)?

Cimetidine Tablets

Generic Name: cimetidine

Brand name: Tagamet HB, Tagamet

Synonyms: Cimetidine

What is Cimetidine Tablets?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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