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Alkeran (Melphalan Injection) and Pharmorubicin Pfs

Determining the interaction of Alkeran (Melphalan Injection) and Pharmorubicin Pfs and the possibility of their joint administration.

Check result:

Alkeran (Melphalan Injection) <> Pharmorubicin Pfs

Relevance: 10.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Limited anecdotal data suggest an increased risk of doxorubicin-induced cardiomyopathy in patients who have previously received melphalan. The mechanism of this suspected interaction is unknown. Although conclusive proof that melphalan sensitizes the myocardium is lacking, anthracyclines should be administered cautiously to patients who have had extensive melphalan therapy.

References

Bitran JD "Doxorubicin cardiotoxicity and melphalan" Ann Intern Med 95 (1981): 243-4

Alkeran (Melphalan Injection)

Generic Name: melphalan

Brand name: Alkeran, Alkeran IV, Evomela

Synonyms: Alkeran (Injection), ALKERAN

What is Alkeran (Melphalan Injection)?

Pharmorubicin Pfs

Generic Name: epirubicin

Brand name: Ellence, Pharmorubicin Pfs, Pharmorubicin RDF

Synonyms: Pharmorubicin Pfs (Intravenous)

What is Pharmorubicin Pfs?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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