All Day Pain Relief and Gengraf (Cyclosporine Oral Solution, Modified)
Determining the interaction of All Day Pain Relief and Gengraf (Cyclosporine Oral Solution, Modified) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using naproxen together with cycloSPORINE can be harmful to the kidneys. Symptoms of kidney damage include swelling, weight gain, feeling short of breath, drowsiness, confusion, mood changes, increased thirst, loss of appetite, nausea and vomiting, pain in your lower back, and urinating more or less than usual or not at all. If you take both medications together, tell your doctor if you have any of these symptoms. You may need a dose adjustment or special tests to safely use these medications together. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Nonsteroidal anti-inflammatory drugs (NSAIDs) may potentiate the nephrotoxic effects of cyclosporine, especially if dehydration is present. The exact mechanism is unknown but is apparently unrelated to plasma cyclosporine levels. The interaction has been reported with diclofenac and sulindac. Data for other NSAIDs are not available, but a similar effect may be expected based on their common pharmacologic action.
MANAGEMENT: Renal function should be closely monitored in patients receiving concomitant therapy with cyclosporine and NSAIDs.
- Brouwers JRBJ, Desmet PAGM "Pharmacokinetic-pharmacodynamic drug interactions with nonsteroidal anti-inflammatory drugs." Clin Pharmacokinet 27 (1994): 462-85
- Sesin GP, O'Keefe E, Roberto P "Sulindac-induced elevation of serum cyclosporine concentration." Clin Pharm 8 (1989): 445-6
- Harris KP, Jenkins D, Walls J "Nonsteroidal antiinflammatory drugs and cyclosporine." Transplantation 46 (1988): 598-9
- Branthwaite JP, Nicholls A "Cyclosporin and diclofenac interaction in rheumatoid arthritis." Lancet 337 (1991): 252
- "Product Information. Arthrotec (diclofenac-misoprostol)." Searle, Skokie, IL.
- Deray G, Le Hoang P, Aupetit B, Achour A, Rottembourg J, Baumelou A "Enhancement of cyclosporine A nephrotoxicity by diclofenac." Clin Nephrol 27 (1987): 213-4
Generic Name: naproxen
Brand name: Aleve, EC-Naprosyn, Flanax Pain Reliever, Midol Extended Relief, Naprelan 375, Naprosyn, Anaprox-DS, Naprelan 500, Flanax, Naprelan, Anaprox, Naproxen Sodium, Aleve Caplet, Aleve Gelcap, Aleve Easy Open Arthritis
Synonyms: n.a.
Generic Name: cyclosporine
Brand name: Gengraf, Neoral, Sandimmune, Sandimmune
Synonyms: Gengraf (Capsules, Modified), Gengraf
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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