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Allegra-D 24 Hour and Zelboraf

Determining the interaction of Allegra-D 24 Hour and Zelboraf and the possibility of their joint administration.

Check result:

Allegra-D 24 Hour <> Zelboraf

Relevance: 24.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Vemurafenib may increase the blood levels and effects of fexofenadine. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration with vemurafenib may increase the plasma concentrations and the risk of adverse effects of drugs that are substrates of P-glycoprotein (P-gp) and/or breast cancer resistance protein (BCRP) transporters, such as dabigatran, rosuvastatin, sulfasazine, and topotecan. The proposed mechanism, based on in vitro data, is decreased clearance due to vemurafenib-mediated inhibition of P-gp and/or BCRP efflux transport proteins.

MANAGEMENT: Caution is advised if vemurafenib is used concomitantly with drugs that are substrates of P-gp and/or BCRP transport proteins, particularly those with a narrow therapeutic range. Some authorities suggest avoiding the use of vemurafenib with drugs that are substrates of these transport proteins and have a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring should be considered whenever vemurafenib is added to or withdrawn from therapy with these drugs. Patients should be monitored for the development of adverse effects.

References

"Product Information. Zelboraf (vemurafenib)." Genentech, South San Francisco, CA.
Cerner Multum, Inc. "Australian Product Information." O 0
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Allegra-D 24 Hour

Generic Name: fexofenadine / pseudoephedrine

Brand name: Allegra-D 12 hour, Allegra-D 24 Hour, Allegra-D 12 Hour Allergy & Congestion, Allegra-D 24 Hour Allergy & Congestion, Allegra D OTC 24HR, Fexofenadine HCl-Pseudoephedrine 12 Hour, Antihistamine & Nasal Decongestant

Synonyms: n.a.

What is Allegra-D 24 Hour?

Zelboraf

Generic Name: vemurafenib

Brand name: Zelboraf

Synonyms: n.a.

What is Zelboraf?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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