Allegra ODT and Clarithromycin Extended-Release Tablets
Determining the interaction of Allegra ODT and Clarithromycin Extended-Release Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration with erythromycin has been shown to increase the oral bioavailability of fexofenadine. The proposed mechanism is erythromycin inhibition of the intestinal efflux of fexofenadine via P-glycoprotein transporter. In addition, erythromycin may decrease biliary excretion of fexofenadine. In 24 healthy volunteers, coadministration of fexofenadine 120 mg twice a day and erythromycin 500 mg every 8 hours resulted in a 82% and 109% increase in the steady-state fexofenadine peak plasma concentration (Cmax) and systemic exposure (AUC), respectively, compared to administration of fexofenadine alone. However, no increase in adverse effects or QTc interval were noted. No studies have been performed using clarithromycin or troleandomycin, but similar results are possible given their similarities to erythromycin. Fexofenadine had no effect on the pharmacokinetics of erythromycin.
- "Product Information. Allegra (fexofenadine)." Hoechst Marion-Roussel Inc, Kansas City, MO.
- "Product Information. Allegra-D (fexofenadine-pseudoephedrine)." Chattem Consumer Products, Chattanooga, TN.
Generic Name: fexofenadine
Brand name: Allegra ODT, Allegra, Aller-Ease, Children's Allegra Allergy, Mucinex Allergy, Wal-Fex, Allegra 24 Hour Allergy, Allegra Allergy, Children's Allegra ODT, Allergy Relief, Allegra OTC
Synonyms: n.a.
Generic Name: clarithromycin
Brand name: Biaxin, Biaxin XL
Synonyms: Clarithromycin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Allegra ODT-Clarithromycin Oral Suspension
- Allegra ODT-Clarithromycin Suspension
- Allegra ODT-Clarithromycin Tablets
- Allegra ODT-Claritin
- Allegra ODT-Claritin Liqui-Gels
- Allegra ODT-Claritin Reditab
- Clarithromycin Extended-Release Tablets-Allegra-D
- Clarithromycin Extended-Release Tablets-Allegra-D 12 hour
- Clarithromycin Extended-Release Tablets-Allegra-D 24 Hour
- Clarithromycin Extended-Release Tablets-Aller-Chlor
- Clarithromycin Extended-Release Tablets-Aller-Ease
- Clarithromycin Extended-Release Tablets-AllerDur