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Aller-Ease and Rifadin IV

Determining the interaction of Aller-Ease and Rifadin IV and the possibility of their joint administration.

Check result:

Aller-Ease <> Rifadin IV

Relevance: 11.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using rifAMPin together with fexofenadine may decrease the effects of fexofenadine. Contact your doctor if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: The coadministration with rifampin may decrease the oral bioavailability of fexofenadine. The mechanism is rifampin induction of intestinal P-glycoprotein, resulting in increased secretion and decreased absorption of fexofenadine. In 24 healthy volunteers divided into 4 groups by age and gender, rifampin (600 mg orally once a day for 6 days) increased the oral clearance of fexofenadine (60 mg single oral dose) in the different groups by 87% to 169% compared to when fexofenadine was administered alone. Mean peak plasma concentration (Cmax) decreased by 32% to 51%, while terminal half-life and renal clearance were not affected. The effect of rifampin on fexofenadine pharmacokinetics was independent of age and sex.

MANAGEMENT: Patients treated with rifampin should be monitored for potentially diminished or inadequate therapeutic response to fexofenadine.

References

Hamman MA, Bruce MA, HaehnerDaniels BD, Hall SD "The effect of rifampin administration on the disposition of fexofenadine." Clin Pharmacol Ther 69 (2001): 114-21

Aller-Ease

Generic Name: fexofenadine

Brand name: Allegra, Aller-Ease, Children's Allegra Allergy, Mucinex Allergy, Wal-Fex, Allegra ODT, Allegra 24 Hour Allergy, Allegra Allergy, Children's Allegra ODT, Allergy Relief, Allegra OTC

Synonyms: n.a.

What is Aller-Ease?

Rifadin IV

Generic Name: rifampin

Brand name: Rifadin IV, Rifadin, Rimactane

Synonyms: n.a.

What is Rifadin IV?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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