Allergy DN PE and Phenytoin Infatabs
Determining the interaction of Allergy DN PE and Phenytoin Infatabs and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using chlorpheniramine together with phenytoin can increase the effects of phenytoin. Contact your doctor if you experience drowsiness, visual disturbances, change in mental status, nausea, loss of muscle coordination, or involuntary movements. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Toxic serum concentrations of phenytoin and involuntary movements have been reported during coadministration with chlorpheniramine. Symptoms resolved after chlorpheniramine was discontinued. The mechanism of this interaction is not known.
MANAGEMENT: Clinical monitoring of patient response, tolerance, and serum phenytoin concentrations is recommended. Patients should be advised to notify their physician if they experience symptoms of phenytoin toxicity (drowsiness, visual disturbances, change in mental status, nausea, or ataxia) or involuntary movements.
- Ahmad S, Laidlaw J, Houghton GW, Richens A "Involuntary movements caused by phenytoin intoxication in epileptic patients." J Neurol Neurosurg Psychiatry 38 (1975): 225-31
- Pugh RN, Geddes AM, Yeoman WB "Interaction of phenytoin with chlorpheniramine." Br J Clin Pharmacol 2 (1975): 173-5
Generic Name: chlorpheniramine / methscopolamine / phenylephrine
Brand name: AH-Chew II, Extendryl JR, Sinodec, Extendryl SR, Prehist D, Dallergy, Extendryl Syrup, Extendryl Chews, Ah-Chew, DA. Chewable, Omnihist LA, Dura-Vent/DA, Hista-Vent DA, DA. II, Liqui-Allergy, Duradryl, Duradryl JR, Drize, Drysec, Ex-Histine, WE Allergy, Chlor-Mes D, Norel SD, Durahist PE, PCM, Omnihist II LA, Ralix, Rescon MX, Aerohist Plus, Denaze, Aerokid, Dallergy ER, Phenylephrine CM, Extendryl Seniors, Dallergy Syrup, DuraTan PE, QV-Allergy, Rescon, AlleRx PE Dose Pack, Redur-PCM, Ah-Chew Ultra, Histatab PH, Chlor-Mes, PCM Allergy, Re-Drylex Jr, CPM-PE-MSC, Triall, SymPak PDX, ScopoHist-PE, Dehistine, DriHist SR, Nohist Plus, Nohist Plus Jr, Dallergy PE, Ah-Chew Ultra Tannate, Duravent, ScopoHist Syrup, Duradryl SR, Duravent-DA, Duradryl Chewable, Allergy DN PE, RelCof PE, RelCof DN PE, Nohist PE
Synonyms: n.a.
Generic Name: phenytoin
Brand name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt
Synonyms: Phenytoin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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