Allergy Multi-Symptom Daytime and Onfi (Clobazam Suspension)
Determining the interaction of Allergy Multi-Symptom Daytime and Onfi (Clobazam Suspension) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:CloBAZam may increase the blood levels and effects of chlorpheniramine. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if you experience increased side effects or your condition changes. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with clobazam may increase the plasma concentrations of drugs that are primarily metabolized by CYP450 2D6. The mechanism is decreased clearance due to inhibition of CYP450 2D6 activity by clobazam. In an in vivo phenotypic cocktail drug-drug interaction study consisting of 18 subjects, dextromethorphan peak plasma concentration (Cmax) and systemic exposure (AUC) increased by 59% and 90%, respectively, when a single dose of the CYP probe substrate cocktail containing dextromethorphan (CYP450 2D6 substrate), midazolam (CYP450 3A4 substrate), caffeine (CYP450 1A2 substrate), and tolbutamide (CYP450 2C9 substrate) was administered with repeated once-daily doses of clobazam 40 mg.
MANAGEMENT: Caution is advised if clobazam must be used concomitantly with medications that undergo metabolism by CYP450 2D6, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever clobazam is added to or withdrawn from therapy.
- Walzer M, Bekersky I, Blum RA, Tolbert D "Pharmacokinetic drug interactions between clobazam and drugs metabolized by cytochrome P450 isoenzymes." Pharmacotherapy 32 (2012): 340-53
- "Product Information. Onfi (clobazam)." Lundbeck Inc, Deerfield, IL.
Generic Name: acetaminophen / chlorpheniramine / phenylephrine
Brand name: Allergy Multi-Symptom, Allergy Multi-Symptom Daytime, Comtrex Flu Therapy Day/Night, Comtrex Severe Cold & Sinus, Contac Cold+Flu Maximum Strength, Gendecon, Protid, Dryphen, Comtrex Flu Therapy, Sinus Congestion & Pain Nighttime, Allergy Relief Multi-Symptom, Tylenol Sinus Congestion-Pain Cool Burst, Relief-PE, Contact Cold and Flu Night, Cold Relief Plus, EQL Effervescent Plus Cold, GNP Cold Relief Plus, QC Cold Relief Plus
Synonyms: Allergy Multi-Symptom
Generic Name: clobazam
Brand name: Onfi, Sympazan
Synonyms: Onfi, Onfi Tablets
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Allergy Multi-Symptom Daytime-Onfi (Clobazam Tablets)
- Allergy Multi-Symptom Daytime-Onfi Tablets
- Allergy Multi-Symptom Daytime-Onglyza
- Allergy Multi-Symptom Daytime-Onivyde
- Allergy Multi-Symptom Daytime-Onmel
- Allergy Multi-Symptom Daytime-Onset Forte
- Onfi (Clobazam Suspension)-Allergy Relief
- Onfi (Clobazam Suspension)-Allergy Relief (Diphenhydramine HCl)
- Onfi (Clobazam Suspension)-Allergy Relief Tablets
- Onfi (Clobazam Suspension)-Allergy Relief-D
- Onfi (Clobazam Suspension)-Allergy Relief/Nasal Decongest
- Onfi (Clobazam Suspension)-Allermax