Alli and Coumadin Injection

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using warfarin together with orlistat can cause you to bleed more easily. You may need a dose adjustment in addition to testing of your prothrombin time or International Normalized Ratio (INR). Call your doctor promptly if you have any unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with orlistat may potentiate the hypoprothrombinemic effect of oral anticoagulants. The proposed mechanism is orlistat reduction of the absorption of vitamin K, a fat-soluble vitamin and cofactor in the synthesis of blood clotting factors that are inhibited by oral anticoagulants. In addition, dietary changes often prompted by orlistat use may also alter vitamin K intake and contribute to the interaction. A case report describes a 66-year-old patient stabilized on warfarin who was found to have an increased INR during a follow-up visit 18 days after starting orlistat. A significant reduction in warfarin dosage was subsequently required to maintain INR in the therapeutic range while receiving orlistat.

MANAGEMENT: Patients should be closely monitored during concomitant therapy with oral anticoagulants and orlistat. The INR should be checked frequently and anticoagulant dosage adjusted accordingly, particularly following initiation or discontinuation of orlistat in patients who are stabilized on their anticoagulant regimen. Patients should be advised to promptly report any signs of bleeding to their physician, including pain, swelling, headache, dizziness, weakness, prolonged bleeding from cuts, increased menstrual flow, vaginal bleeding, nosebleeds, bleeding of gums from brushing, unusual bleeding or bruising, red or brown urine, or red or black stools.

Alli

Generic Name: orlistat

Brand name: Alli, Xenical, Alli

Synonyms: alli

What is Alli?

Coumadin Injection

Generic Name: warfarin

Brand name: Coumadin, Jantoven

Synonyms: Coumadin

What is Coumadin Injection?