Alli and Cytomel

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Taking liothyronine and orlistat at the same time may reduce the blood levels of liothyronine. You should take these medications at least four hours apart. In addition, your doctor may need to monitor your thyroid function more frequently. Let your doctor know if your condition changes or if you experience symptoms like tiredness, sluggishness, muscle weakness or pain, stiffness or swelling in the joints, depression, constipation, hoarseness, unexplained weight gain, hair loss, brittle nails, pale or dry skin, cold intolerance, memory problems, confusion, or menstrual irregularities. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSING INTERVAL: Orlistat may interfere with the gastrointestinal absorption of levothyroxine and other thyroid hormones. The exact mechanism of interaction is unknown. In one case report, symptomatic hypothyroidism occurred within two weeks following the initiation of orlistat in a patient with thyroid cancer who had been receiving levothyroxine for 18 months to suppress thyroid-stimulating hormone production after a total thyroidectomy and radioiodine ablation. The patient complained of tiredness, lethargy and cold intolerance, and thyroid function tests revealed profound hypothyroidism. Symptoms improved two weeks following the discontinuation of orlistat and an increase of levothyroxine dosage from 250 to 300 mcg/day. Laboratory values returned to normal another two weeks later.

MANAGEMENT: Orlistat and oral thyroid hormone preparations should be administered at least 4 hours apart. Close clinical and laboratory monitoring of thyroid function is recommended. Patients should be advised to contact their physician if they experience symptoms of hypothyroidism such as fatigue, muscle weakness or pain, joint stiffness, depression, constipation, hoarseness, weight gain, hair loss, brittle nails, pale or dry skin, cold intolerance, memory problems, confusion, or menstrual irregularities.

Alli

Generic Name: orlistat

Brand name: Alli, Xenical, Alli

Synonyms: alli

What is Alli?

Cytomel

Generic Name: liothyronine

Brand name: Cytomel, Triostat

Synonyms: n.a.

What is Cytomel?