Allopurinol and Videx Pediatric

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using didanosine together with allopurinol is not recommended. Combining these medications can increase the blood levels of didanosine to dangerous levels. This may increase the risk of severe injury to the pancreas, liver, muscles, and nerves. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

CONTRAINDICATED: Coadministration with allopurinol may significantly increase the plasma concentrations of didanosine. The proposed mechanism is allopurinol inhibition of didanosine first-pass metabolism via xanthine oxidase. In two patients with renal impairment (CrCl = 15 and 18 mL/min), allopurinol (300 mg/day) increased the area under the plasma concentration-time curve (AUC) of didanosine (200 mg single dose) by approximately 4-fold. In fourteen healthy volunteers, the mean AUC of didanosine (400 mg single dose) was increased about 2-fold by allopurinol (300 mg/day for 7 days). In one study, four patients treated with an antiretroviral regimen containing didanosine (four 100 mg chewable tablets/day) were able to maintain similar didanosine plasma levels and antiretroviral competency with half the dosage of didanosine during coadministration with allopurinol (300 mg/day). These effects persisted after several months of concomitant treatment.

MANAGEMENT: Because elevated plasma levels of didanosine may be associated with increased risk of serious adverse effects such as pancreatitis and peripheral neuropathy, as well as increased serum uric acid concentrations, the concomitant use of didanosine and allopurinol is considered contraindicated.

Allopurinol

Generic Name: allopurinol

Brand name: Zyloprim, Lopurin, Aloprim

Synonyms: n.a.

What is Allopurinol?

Videx Pediatric

Generic Name: didanosine

Brand name: Videx, Videx EC

Synonyms: Didanosine

What is Videx Pediatric?